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KMID : 0378019700130050043
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New Medical Journal
1970 Volume.13 No. 5 p.43 ~ p.48
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Experimental Studies on the Influence of Ginseng and Sex
Hormone on the Mesenteric Mast Cells of Male Rats
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Abstract
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A total of 35 mature, male Swiss albino rats, each weighing about 200 gm, were divided into five experimental groups, each group consisting of seven rats- normal, castrated, testosterone administered after castration, ginseng administered after castration, castrated after ginseng administration and again ginseng administered, and observation was made on the behavior of tissue mast cells which appeared in the mes
entery with the following results.
1. In the normal male rats, the total relative number of tissue mast cells in the mesentery was 3 0, and most of them were of a rich granular type and there appeared very few mast cells of a poor granular and a disrupted granular type.
2. In the castrated animals, the total relative number of tissue mast cells was 22.95, which shows a considerable decrease compared with that in the normal rats. In this case, the greater part of the bast cells were of a rich granular type, but the number of cells of a poor granular type and a disrupted granular type showed a marked increase.
3. In the group given testosterone following castration, the total relative number of the same cells was 30.02, and the total relative number of cells of each type was similar to that of the normal group.
4. In the group given ginseng after castration and the group which was castrated after ginseng administration and again given ginseng, the total relative numbers of tissue mast cells were 42. 83 and 40.93 respectively, both of which are considerably larger than that of the normal group (32.30) and that of the castrated group (22. 93).
To summarize the above, it may be concluded that testosterone functions in the way to maintain the number of cells resulting from the discharge and disappearance of secretory granules in tissue mast cells. On the other hand, ginseng seems to have power to recover the deterioration due to lack of testosterone resulting from castration, particularly the loss of cells, and furthermore to increase the number of cells even to the level above normal. This leads the author to believe that ginseng does a protective function for tissue mast cells.
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